England face Spain at Wembley on Tuesday in Gareth Southgate's final match in interim charge of the national team.
The 46-year-old is the hot bookmakers' favourite for the job, made vacant by Sam Allardyce in September, and tightened his grip with a 3-0 win over Scotland on Friday night.
It was confirmed on Monday that England captain Wayne Rooney would not start the game following his absence from training due to a "minor issue".
Meanwhile, Spain are unbeaten under new coach Julen Lopetegui, scoring 17 goals and conceding just once in his five games in charge.
They saw off Macedonia 4-0 on Saturday in World Cup qualifying and sit top of Group G after four games.
Team news
Alongside Rooney, Ryan Bertrand also missed England training on Monday morning for "minor issues", while Harry Kane was released from the squad on Sunday to continue his recovery from an ankle injury. No replacement has been called up for the Tottenham striker.
Reports in the national newspapers suggest Southgate will make three changes to the side that beat Scotland 3-0 on Friday with Jesse Lingard, Jamie Vardy and Nathaniel Clyne coming into the starting line-up in place of Rooney. Daniel Sturridge and Kyle Walker.
Aritz Aduriz, the 35-year-old striker who came off the bench to score on Saturday, could start for Spain, who lost Diego Costa to injury last week.
Koke and Thiago Alcantara are likely to join Sergio Busquets in midfield, while Nacho Monreal could come in for Cesar Azpilicueta.
Opta stats
England have lost just two of their last 15 friendly games (W9 D4 L2) and just one of their last six.
England have won seven and lost just once in their last eight friendly games on home soil (1-2 v Netherlands in March), scoring in all eight games and shipping just four goals in total.
England have lost four of their last five international clashes with Spain, winning once in that period, 1-0 at Wembley in November 2011.
England have failed to find the back of the net in four of those five games, with Frank Lampard's winner in 2011 their only goal in that time.
Including this fixture, each of England's last seven meetings with Spain have been friendlies, with their last competitive clash coming in England's Euro 1996 quarter-final shoot-out win.
On home soil, England have won seven of their nine meetings with the Spanish, although their two defeats have come in the last four home games.
Thirty-six players from Spain have appeared in the Premier League so far this season, second only to English players (143).