Paris St Germain missed out on the chance to top Champions League Group A as they were held to a 2-2 draw by Ludogorets.
A win would have seen PSG through as group winners, but they twice fell behind to their Bulgarian opponents and, with Arsenal beating Basel 4-1, had to settle for second place.
Virgil Misidjan gave Ludogorets a surprise early lead but the hosts' superiority looked to be telling when Edinson Cavani levelled with his 20th goal of the season.
However, Wanderson restored the visitors' advantage on the break and it took until stoppage time for Angel Di Maria to find an equaliser.
Napoli secured top spot in Group B with a 2-1 victory at Benfica as both sides progressed into the knockout stages of the Champions League.
The Italian club knew a draw in Lisbon would be enough to qualify but Benfica needed to win, or rely on Besiktas slipping up against Dynamo Kiev, to seal their last-16 place.
Dynamo Kiev's remarkable 6-0 victory against nine-man Besiktas eased any nerves at the Estadio da Luz but second-half goals from Jose Callejon and Dries Mertens helped secure top spot for the Italians, despite Raul Jimenez's late consolation for the hosts.
Meanwhile, Dynamo Kiev crashed out of the Champions League on a high after crushing nine-man Besiktas at the Olympic Stadium.
Besiktas needed to win to have any hope of advancing to the knockout stages but must settle for a place in the Europa League after being comprehensively outplayed.
Andreas Beck was dismissed in the 29th minute and Vincent Aboubakar followed on 56 minutes - and Beskitas were made to pay as Artem Besedin (9), Andriy Yarmolenko (30 pen), Vitaliy Buyalsky (32), Derlis Gonzalez (45+3), Serhiy Sydorchuk (60) and Junior Moraes (77) all found the net.
Russian side FC Rostov will continue their European adventure in the Europa League having made sure of third place by avoiding defeat in their clash with PSV Eindhoven. It finished 0-0 at the Philips Stadion.
Elsewhere in Group D, Robert Lewandowski's 28th-minute free-kick earned Bayern Munich a 1-0 home triumph over Atletico Madrid, ending the Group D winners' 100 per cent record. Both teams were already assured of their progress.
An Arda Turan hat-trick added to Lionel Messi's early strike made for an easy night for Group C winners Barcelona - 4-0 victors at the Nou Camp against Borussia Monchengladbach.
Pep Guardiola's Manchester City were already assured of second spot, and ended their group campaign with a 1-1 home draw against last-placed Celtic.