Luis Suarez insists Barcelona are the "best team in the world", and that their strong team ethic should see them win a second successive La Liga title.
Barca, a point ahead of Real in the standings, go to Granada at 4pm on Saturday, live on Sky Sports 3 HD with coverage starting at 3.30pm, while Real Madrid are at Deportivo, coverage starting at 3.55pm, on Sky Sports 4 HD.
With the head-to-head record separating sides rather than goal difference, Barca's superior record over Real this season (5-2 on aggregate) means Zinedine Zidane's side must win and hope Barca draw or lose to take the title.
Suarez says a clean sheet in Andalucia is the first priority, but is sure there will be one or two pressurised moments, such is the importance of the occasion.
"It's key to keep a clean sheet, we know that we have what it takes in attack," he said. "We can win the two titles [Barca also play Sevilla in Copa del Rey final on May 22] or lose them.
"We are the best team in the world, and we know the pressure that comes with it, but we depend on ourselves.
"Granada will want to win for their own pride. With the goals and assists, if we win the league they have assisted that, but the collective attitude is part of that too.
"We are aware that the fate is in our hands. We have enough time to win the game. We know there will be difficult moments, as that always happens at this stage of the league."
The Uruguay international has enjoyed a fine second season at the Nou Camp, scoring 56 goals to beat his tally of 25 from last term.
And the former Liverpool forward says his team-mates' trust in him has increased, meaning he receives the ball more frequently in attacking positions.
"Most of my teammates, like Messi or Neymar, have been looking to pick me out more, without me telling them, to give me options to score. It shows our team ethic.
"It is an honour to play at Barcelona with these players around me. On the field and off it they have been really important. This season we have shown we are great team-mates."