With Celtic home and hosed before Grand National weekend, attention now turns to the battle for second place and a top-six spot, not to mention the increasingly fraught fight to beat the drop.
The main event of the weekend is Rangers' visit to Aberdeen on Sunday in a match you can watch live with us on Sky Sports.
Aberdeen are seeking a 11th straight home league win against a Rangers side who have drawn their last two and need a win if their flickering hopes of a second-placed finish are not to be extinguished completely.
While 49 points separate the top six, only nine points stand between Kilmarnock in seventh and Inverness in 12th.
Lee McCulloch's men will be looking to build on their gritty midweek draw against Rangers when they travel to Celtic Park, while Inverness will be eager to exploit any strife in the St Johnstone camp when they host the men from Perth in the Highland capital.
Sixth-placed Partick Thistle took a commendable point off the champions on Wednesday night and tackle Motherwell at Firhill on Saturday while struggling Hearts, winless in three, entertain Dundee and second-bottom Hamilton could drag back Ross County right back into the mire with a win at New Douglas Park.
SATURDAY'S FIXTURES
Celtic v Kilmarnock
Andy Walker's prediction:
Celtic 4-0 Kilmarnock
Key player: Eboue Kouassi
With the title secured, it's time for the Ivory Coast man to show everyone what he's capable of.
Ian Crocker's prediction:
Celtic 2-1 Kilmarnock
Key player: Tom Rogic
Likely to get himself noticed on return from injury. Time to surpass last season's 10 goals.
Hamilton Academical v Ross County
Andy Walker's prediction:
Hamilton 1-3 Ross Co
Key player: Tim Chow
Not always first choice under Jim McIntyre but got a vital goal in midweek win over Dundee.
Ian Crocker's prediction:
Hamilton 1-1 Ross Co
Key player: Ali Crawford
Due a big move. He'd probably like it to be Rangers!
Inverness CT v St Johnstone
Andy Walker's prediction:
Inverness 1-0 St Johnstone
Key player: Gary Warren
I still believe Caley Thistle are capable of a shock victory before the split, a win over an impressive St Johnstone side would surprise everyone.
Ian Crocker's prediction:
Inverness 1-1 St Johnstone
Key player: Greg Tansey
Capable of a telling contribution before departing for Aberdeen.
Hearts v Dundee
Andy Walker's prediction:
Hearts 2-0 Dundee
Key player: Don Cowie
Hearts are looking for leadership at this difficult time, Cowie has the character to step forward.
Ian Crocker's prediction:
Hearts 1-2 Dundee
Key player: Marcus Haber
Canadian striker knows the Scottish scene from his time with St Johnstone.
Partick Thistle v Motherwell
Andy Walker's prediction:
Partick 1-1 Motherwell
Key player: Ryan Bowman
With Louis Moult injured, can the English striker help Motherwell out at this difficult time?
Ian Crocker's prediction:
Partick 1-0 Motherwell
Key player: Kris Doolan
Only on as a sub in midweek. Likely to bother Motherwell from the off.
SUNDAY'S FIXTURE
Aberdeen v Rangers
Andy Walker's prediction:
Aberdeen 3-1 Rangers
Key player: Jonny Hayes
Ten consecutive home wins for Aberdeen, Johnny Hayes' input can make it 11 for Aberdeen in a game where there's no love lost between both sets of supporters.
Ian Crocker's prediction:
Aberdeen 2-1 Rangers
Key player: Niall McGinn
May be on his way but will want to bow out on a high.