Queens Park Rangers' Championship match at Sheffield United on Monday has been postponed following a Covid-19 outbreak at the west London club.
The decision came after QPR contacted the EFL to advise them they did not have sufficient players available for the game to go ahead.
The match, which was scheduled to be broadcast live on Sky Sports, will now be rescheduled at a yet to be determined date.
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A QPR club statement read: "Monday's Sky Bet Championship fixture between Sheffield United and QPR has been postponed.
"QPR have informed the EFL that, following several positive COVID-19 tests among our players and staff, we have insufficient numbers to fulfil the fixture.
"The circumstances surrounding the postponement will now be the subject of an investigation in accordance with EFL regulations. A rearranged date for the fixture will be announced in due course.
"We apologise for any inconvenience caused and will update supporters with further information as soon as it is available."
The EFL confirmed in a statement of their own that the circumstances of the postponement will be investigated by the league.
Fifth-placed QPR are now next scheduled to be in Championship action at home to Swansea on December 18, and they will look to strengthen their grip on the play-off places.
QPR's fixture disruption follows fellow London club and Covid-stricken Tottenham, who saw their matches against Rennes and Brighton called off earlier this week due to an outbreak of their own.
Sheffield United, meanwhile, will have to wait a further eight days before they play again, when they travel to Fulham on December 20, live on Sky Sports Football and Main Event.