Aaron Cresswell will feature in West Ham's squad for the first time this season when they travel to Crystal Palace on Saturday.
The 26-year-old full-back has returned to training this week - almost one month earlier than expected - after suffering a serious knee injury in pre-season.
Before his injury, Cresswell had missed just one Premier League match in two seasons for the Hammers and was in contention for an England call-up.
Manager Slaven Bilic said: "Aaron Cresswell is back and looks sharp. He will be in the squad for Saturday and we will then make a decision."
Fellow defender Havard Nordtveit and striker Jonathan Calleri have also returned to full training following minor injuries.
However, Turkish winger Gokhan Tore will be out for up to six weeks with a quadriceps injury.
West Ham's head of medical and sports science Stijn Vandenbroucke said: "Gokhan injured his quadriceps in training during the international break and is going to be out for four to six weeks."
Sam Byram also suffered a significant hamstring injury in West Ham's last fixture against Middlesbrough and underwent an operation on Saturday to reduce the risk of re-injury.
The pair will join record signing Andre Ayew, striker Andy Carroll and left back Arthur Masuaku on the treatment table.
West Ham are 18th in the Premier League standings and will be aiming to secure a first league win since August when they travel to Selhurst Park for the London derby.