Anthony Taylor will referee Red Monday's showdown between Liverpool and Manchester United at Anfield.
Taylor will have Simon Bennett and Stephen Child as his assistants, with Martin Atkinson named as the fourth official.
Taylor, who refereed at Euro 2016, is from Wythenshawe in Greater Manchester and supports non-league club Altrincham.
He was in charge of United's 2-0 victory over Southampton earlier this season.
Taylor was also in the media spotlight for sending off Stoke City boss Mark Hughes off during their 4-0 defeat to Tottenham Hostpur last month.
Bennett has run the line in a United game already this season - their 2-1 defeat to Manchester City.
Child meanwhile was one of the referee's assistants in Liverpool's 2-1 win over Chelsea.
United have won the last four Premier League games between the two sides, although Liverpool were victorious in the most recent meeting at Anfield, a 2-0 triumph in last season's Europa League.