Manchester United goalkeeper David de Gea will have a scan on the knee injury he sustained at Southampton on Sunday.
De Gea banged his left knee on the post in his failed attempt to keep out James Ward-Prowse's free-kick which doubled Southampton's lead late in the first half.
The Spain international was replaced during the break by Dean Henderson, who has been struggling for game time since returning to the club from his loan spell at Sheffield United.
United manager Ole Gunnar Solskjaer confirmed he will be sent for a scan but praised Henderson, who was making his first Premier League appearance for the club, having only featured in the Carabao Cup and once in the Champions League so far this campaign.
Henderson ended up on the winning side as Edinson Cavani scored twice and set up another to inspire a dramatic 3-2 win for the visitors.
"Let's have a little scan or check on [De Gea]," Solskjaer said. "Hopefully he will be okay for Wednesday but I'm not sure."
"Dean played well though. He is a 'keeper who is used to being vocal. He wants to organise his team. He didn't have big saves to make but he was safe with his hands."
Henderson future under spotlight
The Manchester United manager had said this week that Henderson "wants to stay at Manchester United", amid reports he could leave on loan in January.
Reports emerged over the weekend that Henderson is considering leaving Old Trafford on loan again in January, with his place in England's Euro 2020 squad potentially hanging in the balance.
Speaking before the game, Roy Keane told Sky Sports' the situation was a "very difficult" one for both player and club.
"It's a nightmare scenario for Dean Henderson," Keane said. "He wants to play for Man Utd of course but you want to get better by playing games. If you're not playing week in, week out, he's going to go backwards.
"Come January, are Man Utd really going to let him go? I don't think so because they need cover for De Gea. It's a very difficult situation."