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Chelsea striker Tammy Abraham leapfrogged Sergio Aguero atop the chart after netting a hat-trick in a 5-2 win at Wolves on Saturday - extending his league tally to seven goals from just four starts.
Abraham became the first Englishman to score a hat-trick for Chelsea since Frank Lampard in 2011, while England and club team-mate Mason Mount (No 7) was also among the goals at Molineux.
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Aguero slipped into runner-up spot after Manchester City suffered a shock 3-2 defeat in Norwich, reducing a two-goal deficit before Rodri (No 9) scored a late consolation for the champions.
Teemu Pukki (No 8) retained his top-10 standing, assisting Todd Cantwell and smashing home the winner from close range after Emiliano Buendia dispossessed Nicolas Otamendi in the box.
Liverpool's 'Fab Three' were flying high after a 3-1 win at Newcastle, with Sadio Mane netting twice before substitute Roberto Firmino (No 5) produced a sublime back-heeled flick for Mohamed Salah (No 6) to seal victory.
Abraham was one of five English players to top their club rankings - but it was Tom Cleverley, who last played for England six years ago, who helped Watford instigate an incredible comeback to draw 2-2 against Arsenal.