Will Liverpool match their unbeaten Merseyside derby run? Will Paul Pogba or David Silva be the biggest miss? We look at the weekend's Premier League questions...
It's set to be a huge weekend of football live on Sky Sports, kicking off with West Ham v Chelsea on Sky Sports Premier League from 11.30am on Saturday before five 3pm fixtures.
Newcastle then host Leicester at 5.30pm, before Sunday's action gets underway with Southampton hosting Arsenal at midday.
All eyes will then turn to Derby Day with two of the country's biggest derbies as Liverpool host Everton at 2.15pm before Manchester United and Manchester City do battle at 4.30pm, both live on Sky Sports Premier League.
Ahead of the upcoming matches, we look at the potential talking points from each fixture...
Will David Moyes win his first Hammers game? (West Ham v Chelsea, Saturday, live on Sky Sports Premier League from 11.30am)
It has been a month since David Moyes was appointed at West Ham, but three points still elude him with three losses and one draw under his belt and the club sitting in 19th spot with a -19 goal difference.
But Moyes has a surprising record against sides who are the reigning Premier League champions, having won four of his last five home league games against the current title holders and beat all three Italian managers who were in charge of the reigning champions - Carlo Ancelotti, Roberto Mancini and Claudio Ranieri.
Although Chelsea are unbeaten in their last seven Premier League outings, they have lost three of their last six visits to West Ham in all competitions (W3), meaning that Moyes could snatch a surprise win on Saturday.
Will Watford continue their impressive away scoring form at Turf Moor? (Burnley v Watford, Saturday, 3pm)
Marco Silva has hugely improved Watford's form on the road this term, and the Hornets have scored at least twice in each of their seven away fixtures so far this season and beat Newcastle 3-0 in their last away match.
Indeed, Watford have won 13 points on their travels this season, which is already one more point than in the whole of 2016-17 away from home (12 points from 19 games).
But they will come up against a Burnley side who are famed for their strong defence, having kept four clean sheets at Turf Moor in the Premier League this season, conceding just three goals and never more than once in a match.
Will Crystal Palace continue their unbeaten run? (Crystal Palace v Bournemouth, Saturday, 3pm)
After a dismal start to the season that saw a swift managerial change, Crystal Palace are now unbeaten in their last four Premier League games and pulled themselves off the bottom of the table following a 0-0 draw with West Brom last weekend.
The streak signals real progress for Roy Hodgson's side and the Eagles could match a club record if they can find the back of the net on Saturday, having scored in each of their last four league games at Selhurst Park, netting twice in each game.
They've only ever scored in five consecutive home Premier League games twice before, in September and December 1992, although they are yet to beat Bournemouth at Selhurst Park in the Premier League (D1 L1), with their last home league win against them coming in April 1988.
Will Huddersfield stop the rot against the Seagulls? (Huddersfield v Brighton, Saturday, 3pm)
After an impressive start to the Premier League campaign, Huddersfield have lost their last four matches in the competition, scoring just once - although this did come in a late 2-1 defeat to Man City.
Brighton have also suffered a dip in form in recent weeks as the duo prepare for their first top-flight encounter, losing two and drawing two of their last four games, and have only won one of their last nine away league matches at Huddersfield (D4 L4).
Both sides will be chasing a vital three points with Brighton just two points ahead of their weekend rivals.
A fourth successive draw for the Baggies? (Swansea v West Brom, Saturday, 3pm)
Alan Pardew began his reign at West Brom in a similar fashion to how Tony Pulis ended his - with a draw - taking their tally in the Premier League to three in a row.
But they head to a Swansea side this weekend who currently sit bottom of the table with nine points and have failed to win any of their last eight top-flight games.
However, the Swans have won five of their six home Premier League games against West Brom (L1), including each of the last three, giving Paul Clement some hope of a result for his struggling side.
Will Spurs get their Premier League season back on track? (Tottenham v Stoke, Saturday, 3pm)
It's been a poor few weeks for Tottenham by their standards, drawing two and losing two of their last four Premier League outings which has seen them slip down to sixth in the table - three behind Arsenal in fifth and level on 25 points with Burnley.
But facing Stoke on Saturday could be the perfect chance for Spurs to get back to winning ways in the league, having won each of their last three Premier League matches against the Potters, all by a 4-0 score-line.
Mark Hughes' side will be buoyed by their 2-1 win against Swansea last weekend, though, having failed to win their four previous fixtures before then.
Will it be three in a row for Rafa Benitez and Claude Puel? (Newcastle v Leicester, Saturday, 5.30pm)
There are two sides of the coin to this question, with one side good for Claude Puel but the other would be a new unwanted record for Rafa Benitez.
Puel is aiming to win three consecutive Premier League games for the first time as a manager, while Benitez has never lost three consecutive home matches as a manager in England's top flight, but could do so if Leicester win at St James' Park this weekend.
However, the Foxes have won just two of their last 17 league visits to Newcastle (D1 L14), though their last such visit ended in a 3-0 victory in November 2015.
Will Charlie Austin continue his recent scoring streak? (Southampton v Arsenal, Sunday, 12pm)
It appears that Charlie Austin is finally getting his chance up front for Southampton, and Mauricio Pellegrino's faith in the striker is paying off.
Austin has scored three goals in his last three Premier League matches and has also netted in his two league appearances against Arsenal, but he ended up on the losing side for QPR (both 1-2) on both occasions.
The Gunners will be looking to bounce back from their 3-1 loss to Man Utd last weekend, although they haven't won successive away league games against Southampton since August 1997.
Will Liverpool match their longest unbeaten run against their Merseyside rivals? (Liverpool v Everton, Sunday, live on Sky Sports Premier League from 1pm)
Sunday is set to be a huge Derby Day live on Sky Sports, and Liverpool can match some club history if they beat Everton in the Merseyside derby, which kicks off our coverage.
The Reds are unbeaten in their last 14 games in all competitions against their local rivals, just one game short of their longest such run against their Merseyside rivals (15), which was set between March 1972 and April 1978.
Although Everton's form has picked up in recent weeks - winning and keeping clean sheets in their last two Premier League games - they are winless in 17 successive league visits to Anfield (D8 L9) since a 1-0 win in September 1999 thanks to a Kevin Campbell strike.
Who will be the bigger miss: Paul Pogba or David Silva? (Man Utd v Man City, Sunday, live on Sky Sports Premier League from 4.15pm)
Derby Day is rounded off at Old Trafford, but not all the stars will be on show for the two sides as Manchester United will be without the suspended Paul Pogba while Manchester City are set to miss the injured David Silva.
Both have been vital players for their respective sides this term, with Pogba - who assisted two of Man Utd's three goals against Arsenal last weekend before his sending off - only recently returning from injury while Silva has been ever-present, playing in all 15 Premier League games this season.
The players will be big losses for their respective sides and the derby as a whole, but both sides arguably have enough talent in the ranks to help make up for their absences and ensure the Manchester showdown is a superb spectacle.