The Premier League returns after the midweek European action and it promises to be an important weekend at top and the bottom of the table.
Bournemouth and Tottenham kick things off at the Vitality Stadium on Saturday, live on Sky Sports, before a busy slate of afternoon games, including Arsenal v Middlesbrough and West Ham v Sunderland.
Nissan Super Sunday sees Manchester City host Southampton before a mouthwatering clash between Chelsea and Manchester United which sees Jose Mourinho return to Stamford Bridge for the first time since his sacking in December 2015.
Here's a look at 10 key talking points ahead of the weekend's action...
Cherries to inflict a first Premier League defeat of the season on Spurs? (Bournemouth v Tottenham - Premier League Live, Saturday from 11.30am)
Home form has been the key for Bournemouth so far with Manchester United the only winners at the Vitality Stadium this season.
However, Eddie Howe's side, who are on a run of three straight wins at home, will be given a stern test when unbeaten Tottenham travel to the south coast for a game you can see live on Sky Sports on Saturday.
Bournemouth's only victory over Spurs in any competition came in the 5th round of the FA Cup in February 1957, but Howe's side will be confident of an upset this time around.
Boro to frustrate Arsenal again? (Arsenal v Middlesbrough - Saturday, 3pm)
Arsenal are in fine form coming into Saturday's clash with Middlesbrough.
The Gunners are on a run of sixth straight victories in the Premier League, but they've not had it all their own way in recent clashes with Boro
They've won just one of their last six Premier League fixtures against Middlesbrough, but Aitor Karanka's side are struggling for form at the moment and are without a win in their last six.
Arsene Wenger, who celebrates his 67th birthday on Saturday, will be hoping his side can give him the perfect present.
Will Vardy's scoring drought continue? (Leicester v Crystal Palace, Saturday 3pm)
It has been a frustrating time for Jamie Vardy in front of goal as his run without finding the back of the net continues.
It's been nine games in all competitions for both club and country since Vardy scored and he's found the net just twice in the league so far this season.
At the same point last year Vardy had scored seven goals from the opening eight games, but it's not quite been happening for Vardy or Leicester so far in the league this season.
However, the visit of Crystal Palace could spark good memories for the England striker. He scored the winner in the fixture last season and Claudio Ranieri will be hoping the 29-year-old can get back on track with a repeat performance.
Can the Hammers get back to winning ways at the London Stadium? (West Ham v Sunderland, Saturday 3pm)
West Ham picked up their first premier League win for seven matches with a 1-0 victory at Crystal Palace and now Slaven Bilic will be wanting his side to get back to winning ways at the London Stadium.
Humbling defeats to Watford and Southampton at the Hammers' new home was followed by a 1-1 draw with Middlesbrough, leaving memories of the August's scrappy 1-0 win against Bournemouth long in the distance.
But with bottom of the table Sunderland, who have not won a league game on the road so far this season, the next visitors it represents an excellent opportunity for Bilic's men to move up the table.
Will Allen's scoring streak continue? (Hull v Stoke, Saturday 3pm)
Joe Allen has been in red hot scoring form, finding the net in three consecutive Premier League games for the first time in his career.
The former Liverpool midfielder now has five goals in his last four matches for both club and country after scoring twice in Stoke's 2-0 victory over Sunderland last weekend.
And he will now be bidding to become the first Stoke player to score in four Premier League games in a row when mark Hughes' side travel to Hull.
Can Bradley begin with a bang? (Swansea v Watford - Saturday, 3pm)
Swansea's spirited performance at Arsenal will have given head coach Bob Bradley plenty to think about ahead of his debut at the Liberty Stadium.
The former USA boss drew positives from his side's display at the Emirates Stadium despite succumbing to a 3-2 defeat, their fourth on the spin.
Swansea, who have never lost five on the bounce in the top flight, are two games shy of equalling their worst winless run in front of their own fans - seven games.
Having already delivered an encouraging performance, it remains to be seen whether he can deliver points so soon after his appointment.
Toffees to torment at Turf Moor? (Burnley v Everton - Saturday, 3pm)
Having been brushed aside with relative ease at Southampton on Sunday, the sight on Everton on the horizon will strike fear in Sean Dyche's Burnley.
The Toffees, fresh from frustrating Manchester City, head to Lancashire having won on their last three visits to Turf Moor, while they are unbeaten in their last 11 trips to newly-promoted sides.
The odds may appear stacked against the Clarets but, with both of their Premier League wins coming at home, they clearly reserve their best performances for in front of their own fans. Can they turn the tide against the Toffees?
Baggies to bring the best out of Sturridge? (Liverpool v West Brom - Saturday, 5.30pm)
He was given the nod in what was arguably Liverpool's biggest game of the season but Daniel Sturridge, as has been the case so far this season, failed to deliver.
A two-goal return in eight appearances this season - both of which came against Burton in the EFL Cup - has vindicated Jurgen Klopp's decision to frequently name Roberto Firmino up top for the Reds.
However, as Liverpool look to bounce back from their drab stalemate with Manchester United, this could well be the time to keep faith in the England striker.
Sturridge has scored on both of his appearances against West Brom as a Liverpool player. After a week of mixed performances, could he be the man to restore some consistency?
Positive times ahead for Pep? (Manchester City v Southampton - Nissan Super Sunday, 1.30pm)
After a breathtaking start to life in the Premier League things have rapidly turned sour for Pep Guardiola.
Ten victories from his first 10 games have been followed by four without a win - the latest of which was a 4-0 humbling at the hands of his former club Barcelona.
Things, however, could be about to change as Southampton - a team who have lost each of their last five trips to City - head to the Etihad Stadium.
Pep's 'work in progress' at City has yet to come in for intense criticism while the Premier League embraces his revolution, a fifth game without a victory will lead to questions being asked of City's title credentials.
Jose to haunt Chelsea? (Chelsea v Man Utd - 4pm, Super Sunday)
United's form against Chelsea in the Premier League is nothing short of abysmal. The Blues are unbeaten in their last seven meetings with United, while their tally of 16 wins against the Reds put sees them as firm favourites ahead of kick-off.
United have won just two of their last 19 trips to Stamford Bridge, a fact that could have played a part in their decision to appoint Jose Mourinho - a man who knows the place like the back of his hand - in the summer.
With the exception of his final year, Mourinho seemed unbeatable at the Bridge and he managed to transfer that invincibility when he last travelled there as an opposition manager, winning there with in Inter Milan in 2012.
Having gained a spirited point at Anfield, Mourinho will be hoping his return to Chelsea returns points.