A Taylor Harwood-Bellis header gave Southampton a 1-0 victory at QPR to make it 15 matches without defeat - the Saints' longest unbeaten run since 1950.
The visitors ended the match with 10 men following the 89th-minute sending-off of Shea Charles, but they held on.
Southampton's fine run has included 10 wins and Russell Martin's side, fourth in the Sky Bet Championship, remain very much in the race for automatic promotion.
Rangers, meanwhile, have suffered back-to-back defeats and remain third from bottom, having previously won three matches in a row under recently-appointed boss Marti Cifuentes.
- Championship fixtures | table | highlights
- NOW Sports Month Membership: £21 a month for 6 months
- Get Sky Sports | Download the Sky Sports App
The R's have improved since the Spaniard took over and were on the front foot for much of the first half, with the outstanding Ilias Chair their main threat.
Chair almost embarrassed goalkeeper Gavin Bazunu with an audacious attempt from near the halfway line which drifted just over.
The Rangers forward also dispossessed Will Smallbone to set up Elijah Dixon-Bonner, who shot over, and then set up Andre Dozzell, whose shot was deflected over by Flynn Downes.
Chair worried Southampton again when he tricked his way past James Bree before seeing his low strike saved by Bazunu.
Bree was given a torrid time by Chair and was not helped by sustaining what looked like a hamstring injury early on.
He was replaced just after the half-hour mark by former QPR man Ryan Manning, who made an immediate impact, posing a threat on the left-hand side and delivering a free-kick from the opposite flank which led to the goal three minutes before half-time.
Manning swung the ball in and Harwood-Bellis got away from right-back Reggie Cannon to head Adam Armstrong's flick-on past keeper Asmir Begovic.
It knocked the stuffing out of Rangers, who tried hard to conjure an equaliser in the second half but struggled to create openings.
Chair remained a handful but fellow playmaker Chris Willock failed to make an impact, sending one effort well over before going off after suffering an injury - a potential concern for Cifuentes ahead of some crucial matches over the festive period.
The Saints were always dangerous on the counter-attack and Begovic prevented a second goal by producing a fine save to deny Stuart Armstrong.
Charles, on as a second-half substitute, was dismissed for a second yellow card following a foul on Albert Adomah.
The managers
QPR's Marti Cifuentes:
"I'm disappointed because of the result. We want to win matches and today we were not good enough to do it.
"At the same time, I can feel proud and encouraged about what's coming because I saw a team that produced a good performance and tried to play positive, attacking football against one of the best sides in the league.
"We made things very difficult for Southampton. We had a good period in the first half and then unfortunately we conceded a goal from a set-piece.
"At half-time we spoke about putting a lot of pressure on them and I think the guys did that excellently.
"Perhaps we lack this clinical part in the last third, because we got in a lot of situations but should have produced more.
"Overall a very positive performance, but when you lose games you can never be satisfied."
Southampton's Russell Martin:
"Shea took one for the team, which is unfortunate for him but was a big moment because such a strength of theirs is on the counter-attack.
"(I'll criticise) if you get sent off for something stupid - dissent or a wild tackle and all that stuff.
"If you're on a yellow card and one of their biggest threats is the counter-attack, I think it's a good foul. There are good fouls in the game and that was one.
"Now he misses a game, but I'm never going to criticise someone for taking one for the team."