Manchester City and Leicester will raise the curtain on the 2021-22 campaign by playing the Community Shield on August 7.
City, who have won the silverware six times, take on the FA Cup winners at Wembley seven days before they begin the defence of their Premier League title.
The game will kick off at 5pm, with the Football Association to advise on crowd numbers at a later date.
City produced a dominant campaign to regain the Premier League title, eventually finishing 12 points clear of second-placed Manchester United.
Leicester knocked out Manchester United in the FA Cup last eight before going on to beat Chelsea in the final, claiming a first trophy since their Premier League triumph in 2016.
There could be a new look to Manchester City, with chairman Khaldoon Al Mubarak having confirmed the club will sign a replacement for record goal-scorer Sergio Aguero, who has departed the club to join Barcelona.
Several players from both clubs will be on international duty over the summer, with Euro 2020 set to end on July 11, and it remains to be seen whether players could be given extra time off by their clubs following a condensed 2020-21 season.
What's next? Euros, transfer window, 2021/22 key dates
Euro 2020 kicks off on Friday June 11 - just 19 days after the conclusion of the 2020/21 Premier League season - and runs until Sunday July 11.
The 2021/22 Premier League campaign will start on the weekend of Saturday August 14 - 34 days after that Euro 2020 final at Wembley.
- 2021/22 season - all the key dates
- 2021/22 fixture release dates
- Summer transfer window 2021 - what you need to know
- Premier League kits for 2021/22
Clubs will be able to start planning for the new term when the top-flight fixtures are released at 9am on Wednesday, June 16 but transfer business can start in earnest before then, with the summer transfer window opening on Wednesday June 9.