Pep Guardiola and Jose Mourinho go head to head live on Sky Sports on Thursday evening.
Manchester City are one point ahead of Manchester United in the table - but Alex McLeish believes they need a win more than their rivals.
It won't just be local pride at stake in the Manchester derby as the result could be pivotal in the race for the top four.
After their FA Cup exit, does Guardiola need a win more than Mourinho?
Sergio Aguero is a doubt for the game, while Untied will be without injured Zlatan Ibrahimovic. We ask which player will be a bigger miss for their team.
We also preview Tottenham's trip to Crystal Palace which is live on Sky Sports on Wednesday night.
Will Mauricio Pochettino's side be able to cut Chelsea's lead back to four points and who will be the key men at Selhurst Park?
Premier League Daily airs on Sky Sports News HQ every weekday morning from 10am.