Following a week of World Cup Qualifiers and international friendlies, we take a look to see how Premier League players have been affected.
With qualifiers taking place around the world, there were plenty of important goals scored along with some significant injuries.
Here's a round-up of how players from your Premier League team got on...
Arsenal
Shkodran Mustafi played the full 90 minutes of Germany's 2-0 friendly win over Finland but received treatment on an ankle injury. He was then an unused substitute in the 3-0 win over Norway on Sunday night.
Mesut Ozil came on as a sub for Germany against Finland, scoring a deflected goal in the 2-0 win, before playing the full 90 minutes in that 3-0 win over Norway.
Alexis Sanchez played the full 90 minutes in Chile's 2-1 defeat by Paraguay on Thursday. The Arsenal forward cut a frustrated figure once again on Wednesday, as his country were held at home by Bolivia. He played the full game.
Laurent Koscielny started for France and played 83 minutes in their 3-1 friendly win over Italy on Thursday while Olivier Giroud got on the scoresheet during his 45 minutes of action. Both players started the 0-0 qualifying draw with Belarus on Tuesday night, but Giroud was particularly disappointing and was taken off with ten minutes remaining.
Theo Walcott came on in the 71st minute of England's 1-0 win over Slovakia on Sunday while Mohamed Elneny (Egypt) played 90 minutes in a 1-1 draw against Guinea.
David Ospina kept a clean-sheet for Colombia in their 2-0 win over Venezuela on Thursday but was beaten twice as his side lost 2-1 against Brazil on Wednesday.
Granit Xhaka was sent off in stoppage time of Switzerland's 2-0 qualifying win over Portugal on Tuesday. The red card capped a disappointing week for Xhaka, who had hoped to switch national allegiance to Kosovo. However FIFA have ruled that his appearances at Euro 2016 makes him ineligible.
Bournemouth
Joshua King played the first half of Norway's 1-0 friendly defeat by Belarus on Wednesday, before playing 72 minutes and being booked in the 3-0 defeat by Germany on Sunday night.
Brad Smith and Adam Federici clocked up the air miles, playing in Perth on Saturday and then flying to UAE on Tuesday. It was a successful trip as they helped Australia beat Iraq 2-0 in a World Cup qualifier on home soil - Smith played the full 90 minutes while Federici was on the bench - before securing a 1-0 win in the UAE - Smith again playing the full game while Federici was an unused substitute.
Harry Arter and Marc Wilson both played the full 90 minutes of Republic of Ireland's 4-0 friendly win against Oman, but were unused substitutes in the 2-2 draw with Serbia on Monday.
Burnley
Jeff Hendrick and Stephen Ward both came on at half-time in Republic of Ireland's 4-0 win over Oman on Wednesday. Hendrick then started and scored in the 2-2 draw against Serbia on Monday, while Ward started and was brought off with 20 minutes remaining.
Scott Arfield is away with Canada and played all 90 minutes in their 2-1 defeat to Honduras. He played the full game again in Canada's 3-1 win over El Salvador on Wednesday, but his country have now been eliminated from World Cup qualifying.
Tom Heaton was an unused substitute in England's 1-0 win at Slovakia on Sunday night while Steven Defour came on as an 87th-minute substitute in Belgium's 2-0 defeat to Spain on Thursday. Defour did not come off the bench during Belgium's 3-0 win over Cyprus on Wednesday.
Chelsea
Thibaut Courtois made some good saves in Belgium's 2-0 defeat to Spain on Thursday and kept a comfortable clean-sheet against Cyprus on Tuesday. Meanwhile, Eden Hazard played the full 90 minutes in Belgium's defeat to Spain, before producing an improved display in the full qualifier, setting up his side's final goal in the 3-0 victory and also winning a penalty.
Diego Costa replaced Alvaro Morata after 27 minutes for Spain and should have scored, but saw his chance saved by Courtois while Cesar Azpilcueta came on for Jordi Alba in the second half.
Michy Batshuayi was an unused substitute in the 2-0 defeat, but did come on against Cyprus on Tuesday, only to fluff a great chance when put through on goal by Hazard before missing a penalty (again won by his club team-mate)
Costa did, however, grab two headers as Spain beat Liechtenstein 8-0 on Monday night, but Azpilicueta was an unused substitute.
Gary Cahill won his 47th cap for England, playing the full 90 minutes in their 1-0 win at Slovakia on Sunday night.
N'Golo Kante played the full 90 minutes of France's 3-1 win over Italy in a midfield three alongside Paul Pogba and Blaise Matuidi. But Kante was unable to help France to a qualifying win over Belarus, playing the full 90 minutes in the goalless draw.
Willian started for Brazil in their 3-0 win over Ecuador but was replaced after an hour, and was once again replaced after 66 minutes in their 2-1 win over Colombia on Wednesday.
Asmir Begovic played the whole 90 minutes and kept a clean-sheet as Bosnia and Herzegovina beat Estonia 5-0 on Tuesday.
Branislav Ivanovic captained Serbia in their 2-2 draw with Ireland on Monday, but saw the ball deflect off his foot for Ireland's opener in Belgrade.
Victor Moses and John Obi Mikel both played the full game as Nigeria beat Tanzania in a dead-rubber match on Saturday.
Crystal Palace
Yohan Cabaye withdrew from France selection due to a "slight" groin injury but is expected to be available for selection on Saturday for Palace against Middlesbrough.
James McArthur also pulled out Scotland's squad due to a groin injury.
Steve Mandanda played full game in France's 3-1 friendly win over Italy, stepping in for the injured Hugo Lloris. He then played the full 90 minutes against Belarus on Tuesday, keeping a clean sheet in a 0-0 draw.
Christian Benteke was an unused substitute in both Belgium's 2-0 defeat to Spain and 3-0 win over Cyprus.
Wayne Hennessey and Joe Ledley played for Wales in their 4-0 win over Moldova on Monday.
Lee Chung-Yong played 83 minutes and scored South Korea's second goal in a 3-2 win over China on Thursday before playing 90 minutes in their 0-0 draw against Syria on Wednesday.
Everton
Seamus Coleman missed Ireland's 4-0 win over Oman on Wednesday with an ankle problem but played 90 minutes in the 2-2 draw with Serbia on Monday.
Ramiro Funes Mori played the full 90 minutes of Argentina's 1-0 win over Uruguay and their 2-2 draw against Venezuela on Wednesday.
New loan signing Enner Valencia was on the end of a 3-0 defeat to Brazil for Ecuador on Thursday. Things didn't get much better on Wednesday, when Valencia played 90 minutes of Ecuador's 2-1 defeat away to Peru.
Romelu Lukaku and Kevin Mirallas both came on as second-half substitutes as former Everton boss Roberto Martinez lost his first game as Belgium manager 2-0 to Spain. Lukaku started Wednesday's 3-0 win over Cyprus, scoring two goals in a comfortable win.
Maarten Stekelenburg was left on the bench for both Netherlands' 2-1 loss to Greece on Thursday and 1-1 draw with Sweden on Tuesday.
Bryan Oviedo was an unused substitute in Costa Rica's 1-0 win over Haiti on Saturday as was Phil Jagielka for England in Slovakia on Sunday night. But Oviedo started and played 90 minutes as Costa Rica then beat Panama 3-1 on Wednesday.
Ashley Williams captained Wales and played the majority of the game as they beat Moldova 4-0 on Monday night.
Yannick Bolasie played and set up the first goal as DR Congo beat the Central African Republic 4-1 to qualify as group winners in the qualification process for the African Cup of Nations.
Hull
Andrew Robertson played the full 90 minutes and provided a good attacking outlet in Scotland's 5-1 win over Malta on Sunday. However, Robert Snodgrass stole the show and scored a hat-trick and new signing David Marshall played the full 90 minutes.
Adama Diomande was a second-half sub in Norway's 1-0 friendly loss to Belarus on Wednesday, before playing the full 90 minutes in the 3-0 defeat by Germany on Sunday night.
David Meyler was an unused sub in Ireland's 4-0 friendly win over Oman on Wednesday, and again during the 2-2 draw with Serbia on Monday.
Abel Hernandez was an unused sub in Uruguay's 1-0 loss to Argentina on Thursday but came off the bench for the last 15 minutes of his country's 4-0 win over Paraguay on Wednesday.
Ahmed Elmohamady came on as a half-time sub for Egypt in 1-1 friendly draw with Guinea on Tuesday. Their next game is against South Africa on Tuesday.
Leicester
Shinji Okazaki played an hour of Japan's 2-1 loss to UAE on Thursday but did not get off the bench during their 2-0 win over Thailand on Wednesday.
Wes Morgan played 90 minutes as Jamaica went down 2-0 against Panama in a World Cup qualifier, and did the same again as Jamaica lost by the same scoreline to Haiti on Wednesday.
Jamie Vardy and Danny Drinkwater were both unused substitutes in England's 1-0 win at Slovakia on Sunday night.
Riyad Mahrez scored a double for Algeria as they swept aside Lesotho 6-0 in an Africa Cup of Nations qualifier on Sunday evening. New signing Islam Slimani also played and set up Hilal Soudani's goal.
Bartosz Kapustka scored his third goal for Poland in their 2-2 draw with Kazakhstan at the Astana Arena.
Ahmed Musa played 90 minutes as Nigeria beat Tanzania 1-0.
Andy King played 90 minutes for Wales in their 4-0 win over Moldova on Monday.
Liverpool
Divock Origi was picked as the lead striker for Belgium in their 2-0 defeat against Spain. He played 67 minutes, but was not used in the full-qualifier against Cyprus later in the international window.
Sadio Mane was taken off late on in Senegal's 2-0 Africa Cup of Nations qualifier win over Namibia on Saturday evening.
Georginio Wijnaldum scored and played 72 minutes of Netherlands' 2-1 friendly loss to Greece on Thursday and was taken off after 66 minutes in the 1-1 qualifying draw with Sweden on Tuesday.
Adam Lallana and Jordan Henderson (67 mins) and Daniel Sturridge (eight mins) all featured for England as they beat Slovakia 1-0 with Lallana netting the winning goal - his first international strike.
Philippe Coutinho came on for the last half hour in Brazil's comfortable 3-0 win over Ecuador and did the same again against Colombia on Wednesday, setting up Neymar's winner to seal a 2-1 victory.
Emre Can was ruled out of Germany's fixtures against Finland and Norway on Tuesday, following an ankle injury suffered for Liverpool in the EFL Cup.
Estonia captain Ragnar Klavan also missed out through injury against Malta, as his side were held to a draw, but returned in central defence against Bosnia and Herzegovina, only to concede five in the 5-0 defeat.
Simon Mignolet was an unused sub in Belgium's 2-0 friendly loss to Spain and their 3-0 win over Cyprus.
Dejan Lovren was an unused substitute as Croatia drew 1-1 with Turkey on Monday.
Man City
Gabriel Jesus made his full debut for Brazil on Thursday and scored twice in a 3-0 win over Ecuador. It was the start of a new era for Brazil, with former Corinthians coach Tite in the dugout for the first time since replacing Dunga. Jesus started again for Brazil on Wednesday as Tite's won 2-1 against Colombia, with Jesus replaced after 86 minutes.
Kelechi Iheanacho was the match winner for Nigeria, scoring the only goal of the game as the Super Eagles beat Tanzania 1-0 in Africa Cup of Nations qualifying. With Sergio Aguero suspended for Manchester derby on Sunday, Iheanacho could be set to lead the line.
David Silva stole the show for Spain in their 2-0 win over Belgium, scoring both goals - Nolito was an unused sub. Kevin de Bruyne played 87 minutes in that game for Roberto Martinez's team.
Silva again was in fine form on Monday night, scoring twice as Spain saw off Liechtenstein 8-0 in Leon, while Nolito came on at half-time and set up three goals.
Raheem Sterling played 71 minutes in England's 1-0 win at Slovakia on Sunday night while John Stones impressed at the heart of the England defence.
Pablo Zabaleta and Nicolas Otamendi played the full 90 minutes and kept a clean sheet in Argentina's 1-0 win over Uruguay on Friday. The defensive pair did the same again against Venezuela on Wednesday as Argentina battled back from two goals down to draw 2-2.
Man Utd
Anthony Martial scored his first international goal in France's 3-1 win over Italy on Thursday. He played on the left of a front three. Deschamps said: "Martial wasn't satisfied of his performance at the Euros. We talked it over. He was a bit worn out after his busy season. But I haven't forgotten what he's capable of."
Martial was joined in the France team by Paul Pogba, who also played the full 90 minutes and looked full of energy as he builds up his fitness after missing an official pre-season with his new club.
However the pair both disappointed in the goalless draw with Belarus in qualifying on Tuesday, with Martial substituted after an ineffective display and Pogba unable to unlock the home defence.
However, it was bad news for Henrikh Mkhitaryan, who picked up a thigh injury captaining Armenia against Czech Republic, coming off after 38 minutes. Armenia lost 3-0.
David de Gea was his usual reliable self as he kept a clean sheet in Spain's 2-0 win over Belgium, before keeping another clean sheet in the 8-0 win over Liechtenstein on Monday night. Juan Mata watched from the bench for both games.
Emotions were running high for out-of-favour United midfielder Bastian Schweinsteiger as he made his final appearance for Germany in the 2-0 friendly win over Finland on Wednesday.
Daley Blind played the full 90 minutes at centre-back in Netherlands' 2-1 loss to Greece, but was back at left-back for the 1-1 qualifying draw with Sweden on Tuesday.
Wayne Rooney played 90 minutes in England's 1-0 win at Slovakia on Sunday night while Chris Smalling was an unused substitute. Luke Shaw was not involved in the squad after travelling home early. Manager Sam Allardyce wanted to "manage his workload" accordingly. Shaw should be available for United on Saturday against Manchester City.
Sergio Romero kept a clean sheet for Argentina in a 1-0 win over Uruguay as Marcos Rojo watched on from the bench. Romero was then beaten twice by Venezuela but Argentina battled back for a 2-2 draw in Merida on Wednesday. Rojo started the second of the two games, and lasted 83 minutes before he was replaced by Nico Gaitan.
Antonio Valencia was suspended for Ecuador's 3-0 loss to Brazil, but played the full game as his country lost 2-1 away to Peru on Wednesday.
Marouane Fellaini injured his back and sat out Belgium's 2-0 loss to Spain on Thursday, but returned to the starting line-up for the 3-0 win over Cyprus on Tuesday, picking up a booking and being substituted after 84 minutes.
Middlesbrough
Viktor Fischer scored for Denmark against Liechtenstein on Wednesday, before playing 90 minutes and setting up the winner for Christian Eriksen in the 1-0 victory over Armenia on Sunday.
Gaston Ramirez came on as a 70th-minute substitute for Uruguay in their 1-0 loss to Argentina while Cristhian Stuani was an unused sub. The following week, Ramirez was replaced late on during Uruguay's impressive 4-0 win over Paraguay on Wednesday, while Stuani made an 18-minute cameo from the bench.
Brad Guzan played 90 minutes in USA's 6-0 win over St Vincent/Grenadines on Saturday, but dropped to the bench as Tim Howard returned for their 4-0 triumph over Trinidad and Tobago on Wednesday.
Southampton
Fraser Forster was injured on England duty and missed the game with Slovakia. However, his arm injury is not thought to be serious and he's in line to return for Southampton away to Arsenal on Saturday. Alex McCarthy was called in to replace Forster, but was an unused substitute in England's 1-0 win at Slovakia on Sunday night.
Pierre-Emile Hojbjerg played the first half of Denmark's 5-0 friendly win over Liechtenstein, before playing 81 minutes in the 1-0 win over Armenia on Sunday.
Sofiane Boufal was an unused sub in Morocco's 0-0 draw with Albania on Wednesday and he watched on again as they beat Sao Tome and Principe 2-0 on Sunday.
Steven Davis captained Northern Ireland to a 0-0 draw in the Czech Republic while Shane Long played the first half of Republic of Ireland's 4-0 win over Oman on Wednesday.
Dusan Tadic scored a penalty and played the full 90 minutes as Serbia drew 2-2 with Ireland, a game in which Long was brought off in stoppage time.
Virgil van Dijk was an unused sub for Netherlands' 2-1 loss to Greece, but was at centre-back for the full 90 minutes of the 1-1 draw with Sweden on Tuesday, picking up a booking.
Jose Fonte and Cedric Soares were rested by Portugal for the 5-0 win over Gibraltar, but played the full 90 in Tuesday's 2-0 defeat to Switzerland.
Maya Yoshida played the full 90 minutes for Japan in a 2-1 loss to UAE on Thursday. He did the same again against Thailand on Wednesday, helping Japan keep a clean sheet on their way to a 2-0 victory.
Stoke City
Ramadan Sobhi came on as a substitute in the 79th minute of Egypt's 1-1 draw with Guinea and scored what would have been the winning goal, but it was disallowed.
Mame Biram Diouf scored for Senegal in their 2-0 win over Namibia in Africa Cup of Nations qualifying.
Geoff Cameron played 90 minutes in USA's 6-0 win over St Vincent/Grenadines and starred again as they beat Trinidad and Tobago 4-0 on Wednesday.
The week away did wonders for Jonathan Walters, who scored two goals and grabbed an assist in Republic of Ireland's 4-0 win over Oman on Wednesday. Walters then played 90 minutes in the 2-2 draw with Serbia on Monday, alongside team-mate Glenn Whelan, who played the full 90 minutes in Belgrade and the first half against Oman.
Marko Arnautovic set up the second goal of the game as Austria beat Georgia 2-1 on Monday.
Joe Allen scored his first ever international goal and played 90 minutes for Wales in their 4-0 win over Moldova on Monday.
Sunderland
John O'Shea missed Republic of Ireland's 4-0 win over Oman on Wednesday due to a hip problem, but played the full 90 minutes in the 2-2 draw with Serbia on Monday.
Wahbi Khazri got himself on the scoresheet as Tunisia beat Liberia on Sunday night, while Patrick van Aanholt was an unused sub in Netherlands' 2-1 loss to Greece on Thursday and again in the 1-1 qualifying draw with Sweden on Tuesday.
Swansea
Lukasz Fabianski played the full 90 minutes in Poland's 2-2 draw with Kazakhstan on Sunday night.
Ki Sung-Yeung earned rave reviews for his performance in South Korea's 3-2 win over China, but his side were frustrated as he played 90 minutes in a 0-0 draw against Syria on Wednesday.
Jefferson Montero played 73 minutes of Ecuador's 3-0 defeat to Brazil, and put in another 86 minutes in their 2-1 loss away to Peru on Wednesday.
Neil Taylor played 90 minutes for Wales in their 4-0 win over Moldova on Monday.
Gylfi Sigurdsson played the full 90 minutes as Iceland drew 1-1 with Ukraine on Monday.
Tottenham
New £30m signing Moussa Sissoko came on as a substitute after 63 minutes in France's 3-1 friendly win over Italy on Thursday. He then started against Belarus on Tuesday, but was withdrawn after 69 minutes of the goalless draw.
Son Heung-Min was taken off in stoppage time of South Korea's 3-2 win over China on Thursday. He was named man of the match after creating two goals and was allowed to return to London early, missing South Korea's 0-0 draw against Syria on Wednesday.
Toby Alderweireld and Jan Vertonghen played alongside each other at centre-back for the full 90 minutes of Belgium's 2-0 friendly loss to Spain. Mousa Dembele came on at half-time in that match, but didn't feature in the 3-0 qualifying win over Cyprus on Tuesday, with Alderweireld and Vertonghen both playing the full 90 minutes of that game (with the latter at left-back).
Christian Eriksen played the full 90 minutes in Denmark's 5-0 win over Liechtenstein on Wednesday, before scoring the winner but missed a penalty in the 1-0 victory over Armenia on Sunday.
Vincent Janssen played for the full 90 minutes of both of Netherlands' matches during the international window, not scoring in either the 2-1 friendly defeat to Greece or 1-1 qualifying draw with Sweden.
Erik Lamela was an unused sub in Argentina's 1-0 win over Uruguay on Friday but in the absence of Lionel Messi and Sergio Aguero, he started Argentina's 2-2 draw against Venezuela on Wednesday. He was replaced after 67 minutes.
Victor Wanyama started both of Kenya's matches, drawing 0-0 in a friendly against Uganda on Tuesday and 1-1 against Zambia on Sunday.
Danny Rose, Kyle Walker, Eric Dier (all 90 mins), Dele Alli (26 minutes) and Harry Kane (82 minutes) all featured for England in their 1-0 win over Slovakia. Rose played a part in the winning goal scored by Adam Lallana.
Ben Davies played 90 minutes for Wales in their 4-0 win over Moldova on Monday.
Kevin Wimmer was an unused substitute as Austria beat Georgia 2-1 on Monday.
Watford
Juan Carlos Paredes was sent off for Peru in a World Cup qualifier against Brazil. Paredes was given his marching orders on 76 minutes after receiving a second yellow card and did not feature as Peru then beat Ecuador 2-1 without him on Wednesday.
Christian Kabasele was an unused sub in Belgium's 2-0 loss to Spain on Thursday and in their 3-0 victory over Cyprus on Tuesday.
Costel Pantilimon played the full 90 minutes in Romania's 1-1 draw with Montenegro on Sunday night.
Odion Ighalo played but failed to score as Nigeria beat Tanzania 1-0 on Saturday.
Nordin Amrabat played 82 minutes of Morocco's 0-0 friendly draw against Albania on Wednesday.
Jose Holebas played the first half on left of midfield in Greece's 2-1 friendly win over Netherlands on Thursday, but was an unused sub in the 4-1 qualifying win over Gibraltar on Tuesday evening.
Daryl Janmaat was an unused sub in Netherlands' 2-1 friendly loss to Greece on Thursday, but was reinstated at right-back for the 1-1 qualifying draw with Sweden on Tuesday.
Sebastian Prodl was an unused substitute as Austria beat Georgia 2-1 on Monday.
Adrian Mariappa partnered Leicester's Wes Morgan in defence for Jamaica on Wednesday, but could not prevent a 2-0 defeat to Haiti.
Valon Behrami played the full 90 minutes as Switzerland beat the Euro 2016 champions Portugal on Tuesday. Adlene Guedioura (Algeria) are all due to feature for their respective countries on Tuesday.
West Brom
Salomon Rondon played the full 90 minutes of Venezuela's 2-0 loss to Colombia on Thursday, and provided an assist for Josef Martinez in Venezuela's 2-2 draw against Argentina on Wednesday.
Jonny Evans and Gareth McAuley both earned huge praise from Sky Sports co-commentator Gerry Armstrong as they kept a clean sheet in Northern Ireland's 0-0 draw in Czech Republic.
Darren Fletcher captained Scotland for the full 90 minutes in their 5-1 win at Malta on Sunday night while James Morrison was an unused substitute.
James McClean came on as a half-time sub in Republic of Ireland's 4-0 win over Oman on Wednesday and played the full 90 minutes in the 2-2 draw with Serbia on Monday.
West Ham
Dimitri Payet, who is yet to start from West Ham this season, came on as a half-time sub for France in 3-1 win over Italy. Didier Deschamps called on him again against Belarus on Tuesday, but Payet could not unlock their defence in a half-hour cameo in the 0-0 draw.
Darren Randolph came on as a half-time sub in Republic of Ireland's 4-0 win over Oman on Wednesday and then played the full 90 minutes in the 2-2 draw with Serbia.
Cheikhou Kouyate captained Senegal, who beat Namibia 2-0.
Adrian was called up to the Spain squad for the first time but was an unused sub against Belgium on Thursday and Liechtenstein on Monday.
James Collins came on as a late sub for Wales in their 4-0 win over Moldova on Monday.
Angelo Ogbonna played 27 minutes of Italy's 3-1 win over Israel as a substitute.
Gokhan Tore (Turkey) and Michail Antonio (England) were both unused substitutes in their respective games.