Tottenham captain Hugo Lloris will be out for around four weeks with a hamstring injury.
The 29-year-old goalkeeper sustained the injury during the opening stages of Spurs' 1-1 draw with Everton on Saturday, falling awkwardly into the corner of the net after failing to keep out Ross Barkley's fifth-minute opener.
He attempted to play on, but was replaced in the 35th minute at Goodison Park by his understudy Michel Vorm.
A Tottenham statement read: "Following further assessment and scans of the left hamstring injury sustained by Hugo Lloris in the 1-1 draw at Everton on Saturday, we can confirm he is expected to be out of action for around four weeks.
"Our captain left the field during the first half at Goodison Park and our medical team will continue to monitor his progress during his rehabilitation to determine when he will be ready to return to training."
Lloris, who played every game for France as they reached the Euro 2016 final earlier this summer, only returned to pre-season training two weeks ago.
He will miss the upcoming Premier League matches against Crystal Palace, Liverpool and Stoke.