England are chasing the series after losing to Pakistan at Lord's, so what changes will they make for the second Test?
Ahead of the action - which gets underway from 10am on Sky Sports 2 on Friday - we checked in with our pundits and asked them to pick their XIs.
England could make at least two changes, with James Anderson and Ben Stokes both proving their fitness in the County Championship.
It follows reports that England's head coach Trevor Bayliss was unhappy with the decision to leave Anderson out of the squad for the first Test.
Bearing in mind that no-one as yet has looked at the pitch - and assuming Anderson and Stokes are fit - here are the Sky Sports pundits' selections...
Nasser Hussain's XI: Cook, Hales, Root, Vince, Ballance, Bairstow, Stokes, Moeen Ali, Woakes, Broad, Anderson.
Nas says: "Steven Finn and Jake Ball go out, with James Anderson and Ben Stokes back. I'd have Adil Rashid in the squad just in case it's a raging bunsen, which it can be at Old Trafford.
"Moeen Ali's place is under the greatest threat but it would be a little harsh to leave him out after getting 150 two Tests ago. You have to decide who is your best spinner in the conditions, factoring in the rough created outside off-stump by Pakistan's left-armers."
David Lloyd's XI: Cook, Hales, Root, Vince, Ballance, Bairstow, Stokes, Woakes, Rashid, Broad, Anderson.
Bumble says: "Anderson is a very, very experienced player and if he says he's fit, I'd go with him - I think he's sensible enough to say 'I don't think I can get through' or 'I'll be fine', so he's in along with Stokes. They're a given, and Ball and Finn have to give way.
"England need a spinner to take the ball away from right-handers, so I'd go with Rashid over Moeen. I say that having not seen the pitch, though, so England could decide to play two spinners."
Bob Willis' XI: Cook, Hales, Root, Bell, Ballance, Bairstow, Stokes, Rashid, Woakes, Broad, Anderson.
Bob says: "We've got too many players - Hales, Vince, Stokes, Ali, Broad - who bat like they are millionaires and Root's joined the club recently, so we need a level head in there and someone who can play spin, because Yasir Shah is probably the best leg-spinner since Shane Warne and he's going to be the key to this series.
"England have got to find a way to play against him and I don't believe - out of the other batsmen that I've seen - that anybody is as well-equipped as Bell to do that job. I would have picked him but the selectors haven't gone down that road - it's safety first, and Anderson and Stokes will come in for Finn and Ball."
Rob Key's XI: Cook, Hales, Root, Vince, Ballance, Stokes, Bairstow, Moeen Ali, Woakes, Broad, Anderson.
Rob says: "Anderson comes back in if he says he's fit, you've got to go with him. Woakes has been outstanding for the last few Tests, and took 11 wickets at Lord's, so he has to keep his place - that means it's a pretty easy conversation to have with both Finn and Ball, although it's unfortunate for them.
"They could have brought Stokes in for a batsman and played an extra bowler, but now they've gone with Vince and Ballance, they've got to give them a good run of games. I would put Stokes back in at six though, despite Bairstow playing well there - the more responsibility Stokes has had in the past, the more return England have got."
Nick Knight's XI: Cook, Hales, Root, Vince, Ballance, Stokes, Bairstow, Moeen Ali, Woakes, Broad, Anderson.
"I've got Stokes and Anderson coming back in for Ball and Finn. Now they've got some game time behind them with their counties, they naturally demand a place in the team.
"I'd stick with Moeen as the spinner over Rashid. With Pakistan's left-armers creating rough, I would want that off-spin option.
Watch day one of the second Test between England and Pakistan live on Sky Sports 2 from 10am on Friday.