Evin Lewis and Alzarri Joseph put in terrific performances for Windies at The Oval - but it was not enough to earn the tourists a series-saving win.
WATCH highlights of the fourth ODI in the video at the top of the screen as England moved 3-0 ahead in the five-match series after a rain-affected six-run victory on Duckworth-Lewis-Stern.
Lewis hammered 176 from just 130 balls - the opener's second ODI ton containing seven sixes - before retiring hurt with a hairline fracture of the ankle as Jason Holder's side amassed 356-5 in the capital.
Seamer Joseph then claimed five wickets as England tumbled to 181-5 in the 28th over of their run chase - only for Moeen Ali (48no off 25) and Jos Buttler (43no off 35) to respond in style.
Ali and Buttler's stand of 77 in just eight overs lifted England ahead on DLS by the time the heavens opened in the 36th over.
The result was harsh on Lewis, who smashed the fourth-highest ODI score by a West Indian batsman, after Chis Gayle (215) and Sir Vivian Richards (189no and 181).
Lewis will now miss the final ODI at The Ageas Bowl on Friday, a game you can watch live on Sky Sports Cricket (channel 404) from 12pm.